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Model 1 was a univariate regression model, Model 2 was adjusted for demographic characteristics (such as age, gender, education level, marital status, living arrangement, monthly household income, family history of dementia, current drinker), and Model 3 was further adjusted for factors related to COPD [such as FEV1% pred, smoking quantity (cigarettes/day) and duration of smoking]

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With respect to proximal exposure of the fetal brain, as opposed to germline, though fetal smoking exposure is associated with a wide variety of adverse outcomes and birth defects, there appears to be no evidence to support a measurable association between maternal prenatal smoking and ASD in offspring

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